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ea0025p173 | Endocrine tumours and neoplasia | SFEBES2011

Adenosine receptors modulate chromogranin A secretion and growth of neuroendocrine tumours: potential targets for therapy

Kalhan Atul , Garibi Borzo , Jasani Bharat , Kidd Mark , Modlin Irvin , Pfragner Roswitha , Rees Aled , Ham Jack

Introduction: Neuroendocrine tumors of GI tract are a heterogeneous group of rare neoplasms that secrete peptides and amines. These tumors are highly vascular and their vascularity reflects increased tumour related angiogenesis. Adenosine, a major regulator of angiogenesis, is released by enhanced degradation of ATP, during cellular stress, damage and hypoxia.Material and methods: The expression of adenosine receptors (AR) was investigated in two human n...

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ea0046p1 | (1) | UKINETS2016

MicroRNAs associated with small bowel neuroendocrine tumours and their metastases

Miller Helen C , Frampton Adam E , Malczewska Anna , Ottaviani Silvia , Stronach Euan A , Flora Rashpal , Kaemmerer Daniel , Schwach Gert , Pfragner Roswitha , Faiz Omar , Kos-Kudla Beata , Hanna George B , Stebbing Justin , Castellano Leandro , Frilling Andrea

Introduction: Novel molecular analytes are needed in small bowel neuroendocrine tumours (SBNETs) to better determine disease aggressiveness and predict treatment response.Aim of the study: To profile the global miRNome of SBNETs, and identify microRNAs (miRNAs) involved in tumour progression for use as potential biomarkers.Material and methods: Two independent miRNA profiling experiments were performed (n=90), including pr...

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Endocrine Abstracts

Adenosine receptors modulate chromogranin A secretion and growth of neuroendocrine tumours: potential targets for therapy

MicroRNAs associated with small bowel neuroendocrine tumours and their metastases

BiosciAbstracts